1986.08-1991.07,中國科學(xué)技術(shù)大學(xué),高分子化學(xué),理學(xué)學(xué)士; 1991.08-1996.07,中科院感光化學(xué)研究所,有機化學(xué),理學(xué)博士; 1996.08-1998.06,中科院感光化學(xué)研究所,歷任助研、副研; 1998.06-2000.06,美國夏威夷大學(xué),博士后; 2000.06-2023.06,中科院理化技術(shù)研究所,歷任研究員、博士生導師、課題組長(cháng)、業(yè)務(wù)處長(cháng)、副所長(cháng)。 2023.07-至今,中科院理化技術(shù)研究所,所長(cháng)。
長(cháng)期從事有機光化學(xué)、光物理領(lǐng)域的基礎和應用開(kāi)發(fā)研究:
(1)光療藥物:研究光敏藥物同生物大分子相互作用機制,發(fā)展對腫瘤細胞和致病菌具有高效光殺傷能力的新型光敏藥物;
(2)光化學(xué)合成:研究光反應的機理及放量技術(shù),利用光化學(xué)反應制備藥物及藥物中間體,探索光化學(xué)反應綠色化學(xué)化工領(lǐng)域的應用。1.科技部973計劃,“重大疾病相關(guān)的若干重要難檢活性小分子細胞內納米傳感研究”:
2.科技部863計劃,“重污染化工行業(yè)清潔生產(chǎn)技術(shù)與示范”;
3.國家自然科學(xué)基金重大項目,“C-H鍵活化和高效轉化的基本科學(xué)問(wèn)題”;
4.中科院戰略性先導科技專(zhuān)項(B類(lèi)),“能源化學(xué)轉化的本質(zhì)與調控:高效太陽(yáng)能光化學(xué)轉化”;
5.中科院知識創(chuàng )新工程重要方向項目:光化學(xué)綠色合成新技術(shù)—16-DPA光敏氧化合成法;
6.國家自然科學(xué)基金委面上項目十余項。1.?????? Qianxiong Zhou, Wanhua Lei, Yongjie Chen, Chao Li, Yuanjun Hou, Baowen Zhang, Xuesong Wang*, Ruthenium(II)-Arene Complexes with Strong Fluorescence: Insight into the Underlying Mechanism, Chem. Eur. J. 2012, 18, 8617-8621.
2.?????? Jingfan Xie, Qianxiong Zhou, Chao Li, Weibo Wang, Yuanjun Hou*, Baowen Zhang,Xuesong Wang*,An unexpected role of the monodentate ligand in photocatalytic hydrogen production of the pentadentate ligand-based cobalt complexes,Chem. Commun. 2014, 50,6520-6522.
3.Yue Zheng, Qianxiong Zhou*,Wanhua Lei, Yuanjun Hou, Ke Li, Yongjie Chen, Baowen Zhang, Xuesong Wang*, DNA photocleavage in anaerobic conditions by a Ru(II) complex: a new mechanism,Chem. Commun.,2015,51, 428-430.
4.Ke Li, Yangyang Zhang, Guoyu Jiang, Yuanjun Hou, Baowen Zhang, Qianxiong Zhou*, Xuesong Wang*, A bivalent cationic dye enabling selective photoinactivation against Gram-negative bacteria,Chem. Commun., 2015, 51, 7923-7926.
5.Qianxiong Zhou*, Yue Zheng, Tianji Wang, Yongjie Chen, Ke Li, Yangyang Zhang, Chao Li, Yuanjun Hou, Xuesong Wang*, A novel azopyridine-based Ru(II) complex with GSH-responsive DNA photobinding ability, Chem. Commun., 2015, 51, 10684-10686.
6.?????? Na Tian, Weize Sun, Xusheng Guo, Jian Lu, Chao Li, Yuanjun Hou, Xuesong Wang*, Qianxiong Zhou*, Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(II) complexes under hypoxic conditions, Chem. Commun., 2019, 55, 2676-2679.
7.?????? Yang Feng, Weize Sun, Xuesong Wang*, Qianxiong Zhou*, Selective photoinactivation of methicillin-resistant staphylococcus aureus by highly positively charged Ru(II) complexes, Chem. Eur. J., 2019, 25, 13879-13884.
8.?????? Na Tian, Weize Sun, Yang Feng, Xusheng Guo, Jian Lu, Chao Li, Yuanjun Hou, Xuesong Wang*, Qianxiong Zhou*, Chloromethyl-modified Ru(II) complexes enabling large pH jumps at low concentrations through photoinduced hydrolysis, Chem. Sci., 2019, 10, 9949-9953.
9.?????? Youchao Wang, Nana Tian, Chao Li, Yuanjun Hou, Xuesong Wang*, Qianxiong Zhou*,Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy, Chem. Commun., 2019, 55, 14081-14084.
10.???? Zhihui Jin, Shuang Qi, Xusheng Guo, Na Tian, Yuanjun Hou, Chao Li, Xuesong Wang*,Qianxiong Zhou*, Smart use of “ping-pong” energy transfer to improve the two-photon photodynamic activity of an Ir(III) complex, Chem. Commun., 2020, 56, 2845-2848.
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